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Joint unloading
About osteoarthritisAbout knee osteoarthritis (OA)

In knee OA, the joint surface begins to break down. This joint surface is normally covered with cartilage, the firm material at the bone ends that acts as a cushion against shocks. As the cartilage of an OA sufferer’s joint wears away, the bone ends may begin to rub against each other, causing pain.


The importance of reducing excess joint load

Research shows that knee OA can begin or progress if the joint is exposed to excess stress or load1,2, which can result in pain and loss of motion. Several conditions can lead to joint overload, including anatomy, injury, or obesity. When too much load is placed on a joint, the progression of joint disease can lead to painful knee OA.3,4,5,6,7. Restoring the joint to normal loading conditions may relieve pain while maintaining healthy cartilage8.


The goals of OA treatment include minimizing pain, restoring normal activity levels, and slowing disease progression. While drugs and certain cartilage repair procedures may temporarily relieve pain, they often do not treat the underlying problems that led to OA. Although some invasive surgical procedures can effectively reduce joint stress, they often involve permanent changes to the joint’s natural anatomy, which may limit future treatment options.

What is the Implantable Shock Absorber
Unique benefits
 Pain relief

Knee joint unloading is clinically proven to provide pain relief

Atlas System unloads up to 13 kg

ISA unloads up to 13 kg

Joint preserving and reversible

Joint preserving and reversible

Advanced carbon fi ber and titanium biomaterials

Advanced carbon fiber and titanium biomaterials

What is the ISA?


The ISA is an implant that works like a shock absorber for your knee. The concept has been validated to provide pain relief for patients since 2008 and was specifically designed to allow OA sufferers to maintain high activity or productivity levels. The ISA is manufactured from advanced biomaterials and has passed durability and biocompatibility testing.

The ISA may be appropriate if you:


  • Suffer from pain on the medial (inner) side of your knee, especially with activity
  • Desire to be more active again
  • Have medial compartment knee osteoarthritis (OA)

The ISA will not cure your osteoarthritis, but it may provide pain relief.


  1. Radin EL. Who gets osteoarthritis and why? An update. J Rheumatol 2005; 32:1136–8.
  2. Block JA, Shakoor N. The biomechanics of osteoarthritis: implications for therapy. Curr Rheumatol Rep 2009; 11: 15–22.
  3. Radin EL, et al. Role of mechanical factors in pathogenesis of primary osteoarthritis. Lancet 1972; 1:519–22.
  4. Radin EL, et al. Response of joints to impact loading. J Biomech 1973; 6:51–7.
  5. Radin EL, Rose RM. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res 1986:34–40.
  6. Burr DB, Radin EL. Microfractures and microcracks in subchondral bone: are they relevant to osteoarthritis? Rheum Dis Clin North Am 2003; 29: 675–85.
  7. Lindsey CT, et al. Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee. Osteoarthritis Cartilage 2004; 12: 86–96.
  8. Radin EL, Burr DB. Hypothesis: joints can heal. Semin Arthritis Rheum 1984; 13:293–302.