Publications

Publications About Moximed^® or the KineSpring^® Knee Implant System:

Allen, et al. Evaluation of a Novel Knee Load-Bypassing Device in a Sheep Model. J Bone Joint Surg Am 2012; 94: 77-84.

Clifford, A et al. The KineSpring load absorber implant: rationale, design and biomechanical characterization. Journal of Medical Engineering & Technology 2011; 35: 65-71.

London, NJ et al. Novel Implantable Load Absorber for the Treatment of Medical Compartment Knee OA, Poster P295, International Cartilage Repair Society Meeting 2010.

London, NJ et al. Clinical and economic consequences of the treatment gap in knee osteoarthritis management. Medical Hypotheses 2011; 76: 887-892.

London, NJ et al. An Extra-Capsular, Load Absorbing Implant for Medial Knee OA, Poster P13, 5th Basel International Knee Congress and Instructional Course, 2011.

Waller, C et al. Unload it: the key to the treatment of knee osteoarthritis. Knee Surgery, Sports Traumatology, and Arthroscopy 2011; 19: 1823-1829.

Presentations About Moximed or the KineSpring Knee Implant System:

Almqvist, Fredrik. Joint Unloading for Knee OA , Lunchtime Symposium, 5th Basel International Knee Congress and Instructional Course, 2011. 

Almqvist, Fredrik. Joint Unloading: The KineSpring System. London Knee Meeting 2011.

Argenson, Jean Noel (Chairman). Take a Load Off: The KineSpring® System as a First Surgical Option for Medial Knee OA. First Open Meeting of the European Knee Associates 2011.

Hayes, David. Assessing the Likely Clinical Effectiveness of a Novel Unicompartmental Absorber, Australian Orthopaedic Association 2009.

Hayes, David. Surgical Technique and Clinical Results for an Extra Capsular Load Absorbing Implant for Patients with Medial Knee OA. Australian Knee Society 2011.

London, Nicholas. Treatment of Medial Compartment Knee Osteoarthritis Using an Implantable Load Absorber: UK and Australian Experience, British Association for Surgery of the Knee 2011.

London, Nicholas. Clinical Experience with the KineSpring System , Lunchtime Symposium, 5th Basel International Knee Congress and Instructional Course, 2011.

London, Nicholas. Bridging the Treatment Gap: A Load Absorber Solution for Young, Active Knee OA Patients, European Federation of National Associations of Orthopaedics and Traumatology (EFORT) 2011.

London, Nick. The KineSpring: An Option for Unicompartmental Medial OA . Warwick Sports Surgery Seminars: Sports Knee Surgery 2011.

London, Nicholas. Treatment of Medial Knee OA: An Alternative to Arthroplasty for Younger Active Patients, SICOT 2011.

Waller, Craig. Joint Unloading to Treat OA: A Practical Option. Australian Orthopaedic Association 2011.

Waller, Craig. The Young OA Knee: A Treatment Dilemma, Australian Orthopaedic Association 2010.

Waller, Craig. Creation of a New and Novel Orthopaedic Implant: Clinical Challenges and Design Solutions. Australian Knee Society 2011.

Key Scientific Publications:

Abnormal kinematics and loading across the knee joint leads to the onset and progression of knee OA.

• Baliunas, AJ, et al. Increased knee joint loads during walking are present in subjects with knee OA. Osteoarthritis Cartilage 2002; 10: 573-9.
• Brandt, KD, et al. Etiopathogenesis of osteoarthritis. Med Clin North Am 2009; 93: 1-24.
• Wilson, DR, et al. The measurement of joint mechanics and their role in osteoarthritis genesis and progression. Med Clin North Am 2009; 93: 67-82.

Excess load initiates and exacerbates knee OA; unloading the knee addresses the root of the problem.

• Radin, EL. Who gets osteoarthritis and why? An Update. J Rheumatol 2005; 32: 1136-8.
• Lafeber FP, Intema F, Van Roermund PM, Marijnissen AC. Unloading joints to treat osteoarthritis, including joint distraction. Curr Opin Rheumatol 2006; 18(5): 519-25.
• Block, JA, Shakoor N. The biomechanics of osteoarthritis: implications for therapy. Curr Rheumatol Rep 2009; 11:15-22.

Impulse loads and repetitive joint stress leads to sclerotic bone thickening, loss of shock absorbing ability, and cartilage degradation.

• Radin, EL et al. Role of mechanical factors in pathogenesis of primary osteoarthritis. Lancet 1972; 1: 519-22.
• Radin, EL et al. Response of joints to impact loading. III. Relationship between trabecular microfractures and cartilage degeneration. J Biomech 1973; 6: 51-7.
• Radin, EL, Rose RM. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res 1986; 34-40.
• Lindsay, CT, et al. Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee. Osteoarthritis Cartilage 2004; 12: 86-96.

Unloading the joint of excess force may renew or restore damaged tissue over time.

• Radin, EL, Burr, DB. Hypothesis: Joints can heal. Semin Arthritis Rheum 1984; 13: 293-302.

The medial compartment bears a greater proportion of normal knee loads, likely leading to higher incidence and faster degradation in this compartment.

• Ledingham, J, et al. Radiographic patterns and associations of osteoarthritis of the knee in patients referred to hospital. Ann Rheum Dis 1993; 52: 520-6.

Weight loss reduces knee loads and the risk of developing osteoarthritis

• Felson DT, Zhang Y, Anthony JM, Naimark A, Anderson JJ. Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med. 1992; 116: 535-9.
• Messier SP, Gutekunst DJ, Davis C, DeVita P. Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis. Arthritis Rheum 2005; 52: 2026-32.